A new study released this month (Sept. ’07):
Intake of vitamin D supplements seems to be associated with decreases in total mortality rates, according to a meta-analysis of randomized controlled trials, the goal standard in research, published in the Sept. 10 issue of Archives of Internal Medicine (Arch Intern Med. 2007;167:1709-1710, 1730-1737).
“Ecological and observational studies suggest that low vitamin D status could be associated with higher mortality from life-threatening conditions including cancer, cardiovascular disease, and diabetes mellitus that account for 60% to 70% of total mortality in high-income countries,” write Philippe Autier, MD, and Sara Gandini, PhD, from the International Agency for Research on Cancer.
These trials enrolled a total of 57,311 participants, and daily doses of vitamin D supplements varied from 300 to 2000 IU.
Nine trials showed a 1.4- to 5.2-fold difference between the intervention and control groups with vitamin D, and this did not change based on the addition of calcium supplements in the intervention.
“Our results also provide reassurance that at ordinary doses, long-term vitamin D supplementation does not seem to be associated with an overall adverse effect,” the authors conclude.
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